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Although the exact mechanism is unknown, this rise in melanocyte activity has been shown to be stimulated by prostanoids, cytokines, chemokines, and other inflammatory mediators as well as reactive oxygen species that are released during the inflammatory process
Overall, however, about 50% of patients with CHF, 2485% of patients with CKD, and 45% of patients with IBD are iron-deficient [33]
Strub T, Ghiraldini FG, Carcamo S, Li M, Wroblewska A, Singh R, et al
Nat Commun 2020;11:2024
