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In line with the energy starvation hypothesis [30], which induced that energy supply scarcity was responsible for the contractile dysfunction in heart failure

10.1186/s40168-018-0441-4 120 ZhuW.GregoryJ

doi: 10.1093/gerona/58.11.b970

The gut microbiota interacts with the host through the intestinal mucosal surface, and the function of the intestinal epithelial barrier is maintained through several functions of a well-balanced gut microbiota, such as the restoration of tight junction protein structure, mucin gene upregulation, and inhibition of epithelial cell binding with pathogenic bacteria