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Description
Results varied between other medication categories
The introduction of wortmannin was found to significantly reverse the expression of PI3K and AKT, as well as the anti-apoptotic and anti-inflammatory effects of Dihexa, resulting in a decrease in the number of neuronal cells present in the cortex and the levels of IL-10, and an increase in the levels of TNF-alpha and IL-1-beta [1]
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However, this combination induced mesoderm formation in human PSCs probably due to the excessive level of Wnt signaling favoring mesoderm formation (Pan et al., 2022)
