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Although our discussion primarily focuses on CYP2D6 and CYP2C19, CYP3A4 also contributes to the metabolism of several SSRIs, including escitalopram (Islam et al., 2022

Collectively, the sesame lignans exhibit a capacity to reduce neuroinflammation and oxidative injury in the PD context, thereby protecting neuronal integrity

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These metabolic changes underpinning neutrophil activity in inflammatory environments are primarily regulated by the cooperative action of NF-B [43, 223], HIF1 [224, 225], and mTOR [211, 226]