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market entry until January 2023 years after biosimilars launched in Europe [14]

Vitamin B6 (pyridoxine) serves as coenzyme and is involved in the metabolism of protein and carbohydrates, the production of insulin and red and white blood cells, and the synthesis of neurotransmitters, enzymes, and prostaglandins

Additionally, in pupil dilation assays, a common point of action of L-NAME/L-arginine was noted (in miosis, both L-NAME and L-arginine antagonized the response to the other)

Clinicians administering the combination have not reported any adverse interaction effects beyond the individual side effects of each compound