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In a rigorous first-principles approach, calculations for low-energy tautomers must be performed in protonated and deprotonated forms, often both in gas and solvent phases, thus representing a significant computational task

A meta-analysis that included data from eight randomized controlled trials with a total of 327 participants with PCOS found reduced-carbohydrate diets, most lowering carbohydrate intake to 4045% of daily calories versus 5560% of calories in control diets, reduced BMI, insulin resistance, and total and LDL-cholesterol levels

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