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glutathione reduces toxicity of epoxides antioxidant system. a Schematics for the reduction Glutathione-Dependent Pathways in Cancer Cells
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Additionally, insufficient intake of vitamins and minerals (like vitamin C, selenium, and magnesium) that support synthesis, can further reduce levels

doi: 10.1016/j.steroids.2011.11.014 49 PalombaSFalboAZulloFOrioJR

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Haematoxylin and eosin staining and examination under a visible light microscope revealed that in the normal (control) group, the wall of the proximal tubule was thick, the lumen was small and irregular, the epithelial cells were cubic or conical, the cell body was large, the boundary was unclear, the lumen surface had a brush edge, and the nucleus, which was located near the basal part, was spherical
