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Sun JW, Collins JM, Ling D, Wang D
Within the IVR domain of Keap1, Cys-273 and Cys-288 are essential for the turnover of Nrf2 in vitro and in vivo , with mutation of either of these residues resulting in the loss of Nrf2 ubiquitination by Keap1 [250, 268]
In contrast, the beta GSTs have a cysteine in place of the serine/tyrosine residue
Reactive oxygen species (ROS)including the superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH)are natural byproducts of aerobic metabolism
