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Between 3 and 5 weeks, demyelination becomes visible, and OPCs are activated and recruited to replace the lost oligodendrocytes (Brousse, 2015)

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After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the oxycodone plasma concentration will decrease [see CLINICAL PHARMACOLOGY], resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to oxycodone and acetaminophen tablets

Duan M, Ulfendahl M, Laurell G, Counter S, Pyykk I, Borg E, Rosenhall U (2002) Protection and treatment of sensorineural hearing disorders caused by exogenous factors: experimental findings and potential clinical application