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Acknowledgments We thank Vilim Simanek, in memoriam, for his guidance on writing this paper

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This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

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Goto K, Okuyama R, Sugiyama H et al (2003) Effects of heat stress and mechanical stretch on protein expression in cultured skeletal muscle cells

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Chronic antigen stimulation and persistent TCR signaling upregulate death receptors such as Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors on activated T cells, increasing their susceptibility to activation-induced cell death (AICD) [304]

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