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Rather, the majority of orally ingested l-carnitine in mice produced a previously unappreciated intermediary metabolite, -butyrobetaine (BB), in a gut microbiotadependent step that occurred at a site anatomically proximal to, and at a rate 1,000-fold higher than the rate of the formation of TMA (26)

PMID 11353742

De Bie MK, Ajmone Marsan N, Gaasbeek A et al (2012) Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants

5.1 pH-sensitive linkers and infectious microenvironments Acidic environments are typical of numerous pathogenic processes and offer targetable physicochemical signals for facilitating selective payload release