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They found that BMSCs and TSG-6 reduced MMP-3 and MMP-13 expression in IL-1-treated NPCs, thus restoring the expression of type II collagen and proteoglycan

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The treatment works by: Activating fibroblasts, the cells that produce connective tissue Increasing collagen synthesis Strengthening the ligaments that stabilize the ribs Improving overall joint stability Over time, this can help reduce rib hypermobility and decrease intercostal nerve irritation