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When using hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, follow patients at frequent intervals and consider increasing the opioid dosage, if needed, to maintain adequate analgesia or if symptoms of opioid withdrawal occur [see PRECAUTIONS, Drug Interactions]
Goto S, Tsuiki H, Soyama N, Okamura A, Yamada K, Yoshikawa M, et al
doi: 10.1002/1878-0261.12095 172 MatsuokaJYashiroMDoiYFuyuhiroYKatoYShintoOet al
