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Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Xu et al., 2024)

Research has demonstrated the antioxidant action of S-Acetyl-glutathione rivals that of vitamins C and E

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A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]