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This results in a concentration gradient of GSH, with the highest levels found in the epithelial and cortical fiber cells, and the lowest levels in the nucleus [14]

Although these results might appear contradictory, they can be reconciled by our histological findings showing a reduction of intracellular/somatic GABA signal at P12, particularly in layer 5, consistent with the selective vulnerability of output-layer circuits rather than pan-cortical degeneration, as GABAergic neuron numbers were relatively maintained across other layers

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