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Additionally, pioglitazone, another insulin-sensitizing drug that exerts its glucose-lowering effects through the activation of peroxisome proliferator-activated receptors, has also been reported to ameliorate cognitive decline

216 Given that one of the important SOD1 functions is buffering copper levels, these data indirectly suggest that UPS components are involved in regulating copper homeostasis

40 Moreover, occludin-null males appeared infertile and did not produce litters when crossed with the wild-type (WT) females
