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CYCS further involved in Fenton-like reactions and lipid peroxidation, ultimately triggering ferroptosis [218]
doi: 10.1186/1744-8069-5-44
One mechanism that has been proposed for how ROS signaling specificity is achieved is confinement of the sources of ROS, such as SODs and NOXs, close to their intended targets (Mittler et al., 2011)
In other cases, the reactive forms of oxygen (singlet oxygen, the superoxide and hydroxyl radicals, hydrogen peroxide), that are not coped with by the natural detoxifying mechanisms, can react with biological structures and impair their physiological function
