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Regenerative medicine-based solutions are being aggressively pursued with the goal of restoring dopamine levels in the striatum, with several emerging techniques attempting to reconstruct the entire nigrostriatal pathwaya key goal to recreate feedback pathways to ensure proper dopamine regulation

Much more important aspects to consider are robustness, simplicity, feasibility and, last but not least, the costs of the method

AANAT is the rate-limiting enzyme of melatonin because it controls the circadian rhythm of melatonin production via the pineal gland

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