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Activity at mu and delta receptors mediates classic opioid effects (e.g., analgesia, euphoria, sedation) while drugs that mimic the endogenous ligand for kappa receptors exert an opposite pharmacologic profile (e.g., increased pain sensitivity, dysphoria)

Thus, SOD plays a crucial role in antioxidant defense in almost all living organisms exposed to the damaging effects of molecular oxygen

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Although some authors have tried to assess the mechanistic link between HLA-II allele expression and the development of ME/CFS, the lack of robust data makes it difficult to support this association (490)