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Among the glycolysis pathway, NRF2 induces the expression of several key glycolytic enzymes, including hexokinase 1 and 2 (HK1/2), glucose phosphate isomerase 1 (GPI1), 6-phosphofructo-2-kinase (PFK2), PFK4, fructose-bisphosphate aldolase A (ALDA), enolase 1 (ENO1), ENO4, pyruvate kinase muscle isoform 2 (PKM2) to increase glycolytic flow and maintain pool sizes of glycolytic intermediates for anabolic reactions [77]

doi: 10.1002/hep.1840160319 71 ZischkaHLichtmanneggerJSchmittSJgemannNSchulzSWartiniDet al

There is both clinical and preclinical evidence of amelioration of symptoms with ITC treatment for these conditions

& Murray, D