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By scavenging excessive ROS, polysaccharides can prevent the activation of pro-tumorigenic pathways (e.g., NF-B and MAPK) that are driven by oxidative stress (136)

This review article elucidates the underlying mechanisms involved in Wnt signaling, as well as the complex interplay between Wnt and other pathways, including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-, nuclear factor kappa, bone morphogenetic protein, N-methyl-D-aspartic acid receptor-Ca 2+ -Activin A, Hippo-Yes-associated protein, toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-, and hepatocyte growth factor/mesenchymal-epithelial transition factor

Considering bladder cancer is not among the most common cancers and has a relatively good prognosis, it may therefore not be justified to target FGFR3 specifically to prevent bladder cancer

Global PGC-1 knockout mice display unexpected metabolic phenotypes - reduced adiposity and increased physical activity despite compromised mitochondrial capacity (123)