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This occurs through the blockade of calcium ion (Ca 2 ) influx and capsaicin-induced cell volume contraction
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44,45 Estrogen appears to modulate pain perception in multiple ways, including through effects on nerve pathways and neurotransmitter function, influencing serotonin, dopamine, epinephrine, and endogenous opioid signaling

Sunlight tends to decrease the efficacy of many ingredients
