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Both the GLS gene encoded enzymes and the GLS2 encoded enzymes require phosphate for activity
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In patients with locally advanced, metastatic, and/or refractory solid tumors and hematological malignancies, CB839 is being evaluated in open-label phase I clinical trials (NCT02071862, NCT02071888, NCT02771626)
FEBS Lett Ishimoto T, Kato Y (2022) Ergothioneine in the brain
