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It just means that no one has studied enough to determine one way or the other

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Pyruvate can be converted to oxaloacetate through anaplerosis to generate citrate through the tricarboxylic acid (TCA) cycle to enhance DNL [155]

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Similarly, other polymorphisms in genes involved in ECM remodeling, collagen metabolism, and other pathophysiological pathways have been observed in sporadic cases of MVP (22)

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doi:10.1196/annals.1320.015

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