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It just means that no one has studied enough to determine one way or the other

Pyruvate can be converted to oxaloacetate through anaplerosis to generate citrate through the tricarboxylic acid (TCA) cycle to enhance DNL [155]

Similarly, other polymorphisms in genes involved in ECM remodeling, collagen metabolism, and other pathophysiological pathways have been observed in sporadic cases of MVP (22)

doi:10.1196/annals.1320.015
