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Epalrestat enhances the chemosensitivity of cancer cells to doxorubicin by inhibiting the activity of AKR1B1 and/or AKR1B10 as well as by preventing epithelial-mesenchymal transition [145]

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Together, they balance each other's effects, with HGH increasing IGF-1 binding proteins to enhance IGF-1 bioavailability and tissue effects
