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IRE1 inhibition reduces ischemic kidney damage Previous studies have established the role of ferroptosis in promoting renal ischemiareperfusion injury (IRI) 2,26,27

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Integrating bibliometric insights with mechanistic foundations Our bibliometric analysis shows that research on H in nephrology, though promising, has progressed irregularly since 2009, with modest publication peaks in 2019 and 2024.11,17 The field remains dominated by original research articles, whereas reviews and meta-analyses are relatively scarce,16 reflecting an emphasis on experimental or early clinical studies over comprehensive syntheses