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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial

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You carefully inject at the musculotendinous junction rather than the tendon body itself to minimize rupture risk

Shaking also creates foam, which dramatically increases the surface area exposed to air and can physically denature proteins and larger peptides through the mechanical forces at bubble interfaces
