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The two mechanisms are independent

If serum values were decisive, even patients with neurological involvement could suffice with the maintenance dose of one injection every two months after the initial loading dose

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m , clamped blood glucose, n , steady state mouse and human insulin levels and o , glucose uptake into metabolically active tissues for a hyperinsulinemic-euglycemic clamp of lean mice following a single injection of vehicle (n = 7 mice) or 325 nmol/kg EB1002 (n = 8 mice)