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By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism

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It can also play a role in mitochondrial dysfunction in the development of cardiovascular problems.[ref] Riboflavin is central to many pathways in health, with insufficiency affecting hair, skin, nails, energy, cognitive function, and reproductive health

However, one review found that treating depression with vitamin B12 didnt reduce the severity of symptoms