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In addition to the column headers highlighted in bold, the log fold-changes are shown in bold for metabolites with increased abundance in de novo PD, and in regular font for metabolites with decreased abundance
VEGFR3 is a tyrosine kinase receptor encoded by the FLT4 gene that regulates lymphangiogenesis [80]
In contrast, other studies have shown that HIF-1 promoted mitochondrial fusion while downregulating fission through HO-1, thereby lessening mitochondrial fragmentation and ROS production [36, 77]
J Biol Chem 256: 1239912404
