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Cochlear Explant Day 0: Dissected whole cochleae were mounted onto Cell-Tak-coated mesh inserts and incubated overnight in growth medium

( B ) The tryptophan-to-phenylalanine substitution at position 65 of the gp34 1-179 sequence designated as gp34 1-179W65F variant was used as a non-Fc binding control

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Lactic acidosis is attributed to mitochondrial DNA gamma polymerase inhibition, resulting in impaired synthesis of mitochondrial enzymes that generate ATP