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*p = 0.04 for Nos-2, p = 0.04 for Ho-1, and p = 0.004 for Gfap versus control (n = 4 per group)

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Upon mPTP opening, cytochrome c (Cyt c) is released from the mitochondrial intermembrane space into the cytosol, initiating the intrinsic (mitochondrial) apoptotic pathway

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