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Knop J, App C, Huff T, Iavarone F, Castagnola M, Hannappel E (2015) Identification of PDGF-BB binding to thymosin 4 by chemical cross-linking

The research was funded by the Koch Institute Dana-Farber Bridge Project and the National Institutes of Health.

A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents

Clinical trials involving approximately 900 participants showed that AOD-9604 had no effect on IGF-1 levels and no negative effects on carbohydrate metabolism