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They not only synthesize different components of dermal matrix, but also produce a number of growth factors that are involved in a multitude of cellular pathways regulating cell migration and proliferation, angiogenesis, epithelialization, and so forth

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Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations