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The release of heme, following the rupture of HO-1 / macrophages, caused further tissue inflammation, with initial splenic enlargement progressing to red pulp fibrosis, atrophy, and functional hyposplenism, that recapitulated the asplenia of an HO-1deficient patient

Hence, ABA induced expression of GhGPX genes may involve enzymatic responses to oxidative stress

R.HouZ.BolinJ

doi:10.1136/gutjnl-2011-301708 27
