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In summary, the information in this paper covers the journey from the basic physiological mechanisms for glutathione synthesis and regulation through to how glutathione ameliorates free radical imbalances at the organ system level (Figure 2)

Consequently, SIRT1 activation represents a promising therapeutic strategy for mitigating DSS-induced UC

In mitochondria, a GSH intracellular transport system located on the inner mitochondrial membrane and that mediates the movement of GSH from the cytosol into the mitochondrial matrix was reported [106,107,123]

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