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Mitochondria, calcium, and cell death: a deadly triad in neurodegeneration
Studies discovered mitochondrial-derived peptide called MOTS-c has been shown to significantly reduce the level of pro-inflammatory factors in mice and increase anti-inflammatory factors and insulin-stimulated glucose treatment rates, as well as glucose homeostasis (79)
All the same, healthy adults should stick to 400mg of caffeine daily

Bodenheimer has received speaker honoraria and research support from Roche Pharmaceuticals and Schering Plough and has served on the advisory board of Roche Pharmaceuticals