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Ubidecarenone enhances succinate-dependent and glycerol-3-phosphate-dependent ROS generation, mitochondrial membrane depolarization, and regulated cell death Impairments to the mitochondrial ETC, in particular the loss of efficiency in electron transfer from Complex III or mGPDH to oxygen (as reported above), can result in electron leakage and ROS generation 10

Therefore, this needs to be clarified

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Although wortmannin is an efficient pan-PI3K inhibitor with relatively satisfactory potency, its low selectivity for other kinases limits the expansion of its applications [167]