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Furthermore, the intricate crosstalk between PCa cells and stromal cells, including Cancer-associated fibroblasts (CAFs), endothelial cells, and adipose stromal cells (ASCs), contributes to the progression of PCa (Heidegger et al., 2022)
Treatment involves dietary optimisation, oral supplementation for mild deficiency, or intramuscular hydroxocobalamin injections for significant deficiency or neurological involvement

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