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Description
Adapted from " Progression of Parkinson's Disease in the Substantia Nigra by BioRender.com (2021)
51 The most prominent metabolic function of SAM is its role as a methyl donor, with over 90% of the SAM produced being consumed in methylation reactions
Up-regulation of the pathway was also able to induce cell proliferation, cell cycle progression, anchorage-independent growth and resistance to chemotherapy-induced apoptosis in medulloblastoma cell lines
Its found in surprisingly high concentrations in most cells, and interestingly in roughly the same concentrations as glucose, potassium, and cholesterol 2
