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Description
( A ) Klver-Barrera Luxol fast blue staining (LFB) and 2, 3-cyclic nucleotide 3-phosphodiesterase (CNPase) immunostaining of myelin in serial brain coronal paraffin sections from representative vehicle- (left column), XPro1595- (middle column), and etanercept-treated (right column) naive mice (CPZ0) or cuprizone-fed (CPZ-fed) CPZ3, CPZ5, CPZ6+1, and CPZ6+4 mice ( n = 8 for vehicle-treated CPZ0, n = 4 for XPro1595-treated CPZ0, and n = 612 for all other time points)

H.AliyuS

Perhaps not significantly for short-term, but careful study is needed

The activation of calpain-2 is associated with numerous downstream consequences, including the cleavage of cytoskeletal proteins into stable proteolytic fragments that can be captured as fluid-based biomarkers (Saatman et al., 2010)
