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Unlike small-molecule drugs, peptide chains are susceptible to enzymatic degradation almost everywhere in the body, including the gastrointestinal tract, the bloodstream, and mucosal surfaces

Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction

Although D-dimer can exist at low levels in the plasma of healthy individuals from the physiologic breakdown of fibrin, elevated levels develop in a number of pathologic conditions [82]