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Think weightlifting, sprinting, or jumping

doi:10.1186/s12888-020-02793-9 92 Fernandes, B

Zone 1 (EU) including Switzerland and United Kingdom: Belgium, Bulgaria, Denmark (except Faroe Islands and Greenland), Estonia, Finland (excluding land Islands), France (except overseas areas and departments), Germany, Greece (except Mount Athos), United Kingdom (except Channel Islands), Ireland, Italy (except Livigno and Campione d'Italia), Croatia, Latvia, Lithuania, Luxembourg, Malta, Monaco, Netherlands (except non-European territories), Austria, Poland, Portugal, Romania, Sweden, Slovakia, Slovenia, Spain (except Canary Islands, Ceuta + Melilla), Czech Republic, Hungary, Cyprus / Republic (except northern part), including Switzerland

In particular, understanding the degenerative mechanisms beyond DS neuropathology may lead to answers to a number of open research questions: 1 ) What is the genetic risk profile for the development of early-onset AD