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Copper Oxide Nanoparticles Stimulate Glycolytic Flux and Increase the Cellular Contents of Glutathione and Metallothioneins in Cultured Astrocytes. Neurochemical Research 40: 1526

HK2-targeting peptides trigger mitochondrial Ca2 + overload, leading to Ca2 + -dependent calpain activation, mitochondrial depolarization and cell death, and can also cause massive death of chronic lymphocytic leukemia B cells (227)
This would promote an allergic tendency in the immune response to various antigenic stimuli
