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Cecal samples were collected at euthanization, then flash-frozen and stored at 80 C

The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption

Overall, these studies highlight the role of adipocyte lipolysis in inter-organ crosstalk through the release of lipid signals and EVs to regulate whole body tissue homeostasis (Figure 4)

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