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Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels

doi: 10.3390/nu12071915

45 Similarly, cachexia in pancreatic cancer patients is highly prevalent and clinically relevant, primarily because of alterations in both exocrine and endocrine pancreatic functions, as well as potential impacts on the structure of other digestive organs or indirect modifications to gut physiology