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This article from Nature explains more about the science of Exosomes and how they can help with osteoarthritis

Moreover, concentrations of circulating endotoxin and the number of bacteria in the intestinal lymph nodes and the lymphatic circulation also correlate with disease severity [80]

In summary: Omega-3s strengthen neuronal membranes and anti-inflammatory signaling, improving executive function, impulse control, and mood stability

This activation stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and most significantly for weight management, reduces appetite through effects on hypothalamic appetite centers