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During physiological conditions, neutrophils are generated through steady state granulopoiesis, where about 10 11 neutrophils per day are released from bone marrow and this process is regulated by a master transcription factor CEBP in association with chemokine axis, adhesion molecules and growth factors

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The NLRP3 inflammasome is a complex consists of a sensor (NLRP3 protein), an adaptor (apoptosis-associated speck-like protein, ASC), and an effector (caspase-1)

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