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doi: 10.1172/JCI119537

Proline accumulation, a compatible solute Numerous studies have shown the accumulation of proline, a key compatible solute, plays a central role in stress tolerance [3], while antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and glutathione S-transferase (GST), together with antioxidants such as flavonoids and phenolics mitigate oxidative damage by neutralizing reactive oxygen species [6]

American Journal of Physiology-Endocrinology and Metabolism, 282 (2), E474-E482

Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart