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Under certain pathological states of mitochondrial dysfunction, this rate of conversion to reactive oxygen species may increase as a result of leakage of electrons from the electron transport chain and the subsequent reduction of oxygen to superoxide

Activation of C3aR inhibits the adenylyl cyclase pathway, and stimulates the phospholipase C pathway, leading to Ca 2+ signaling originating from the endoplasmic reticulum Ca 2+ store 455